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  • Research and Innovation

    Research Facilities


The Dubrowsky Regenerative Medicine Laboratory

About the lab

In 2014, former ROH patient, Mr Michael Dubrowsky passed away and left a significant legacy gift to the Trust following treatment he received here for chondrosarcoma. This generous gift enabled us to invest in a state-of-the-art regenerative medicine laboratory - The Dubrowsky Regenerative Medicine Laboratory. The laboratory was officially launched on 17 December 2019.

Dubrowsky Regenerative Medicine Laboratory Virtual Tour

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You can take a virtual tour of our state of the art Dubrowsky Regenerative Medicine Laboratory below. Move around the facility using the white navigation icons along the bottom of the tour - just hover over each icon for details. To navigate to a specific room, use the ‘thumbnail menu’ icon. Press the ‘auto rotate’ icon or move your mouse/device around to move in 360 degrees. For the best view enter ‘full screen’ mode. In each room you can click on the ‘info’ icons to discover more about the facilities available in the laboratory.


Current Laboratory Projects

Project 1

The use of Affinity Selection Systems for intraoperative cell salvage.

The use of red blood cell salvage, has become commonplace in surgery, and orthopaedics specifically. This recycles the patient’s own red blood cells back to the patient during the surgery which has a range of benefits. It reduces and in some cases, negates the need entirely for blood transfusions, as well as reduce the risk of infection for the patient. There is also evidence that this can reduce issues of compatibility for future pregnancies in young ladies.

Project 2

The generation of a biological glue for bone regenerative medicine.

Osteoarthritis is where an inflammatory and deteriorating process occurs inside a joint leading to the loss of cartilage, exposure of the underlying bone and intense pain for the patient. This loss of cartilage means that the patients present with pain, stiffness and loss of function. Patients with osteoarthritis require long term medical and surgical therapy in the form of medication, physiotherapy and eventually surgery (often seen as total joint replacement).

Project 3

The use of biologically active bioglass in the management of osteosarcoma.

Osteosarcoma is a type of cancer that produces immature bone. It is the most common type of cancer that arises in bones, and it is usually found at the end of long bones, often around the knee.

Curative procedures for primary bone cancer such as osteosarcoma leave a bony defect which needs to be filled with a something. This could be an endoprosthesis, an allograft (piece of donor bone) or the patient’s own sterilised bone from another part of the body to allow continued limb function. This is known as a curative resection.

    Partners

    Partners involved in work in the lab include Aston University.

    Research tissue bank

    Our research tissue bank was established over twenty years ago and contains the world’s largest archive of frozen bone tumour samples. This unique research resource currently holds over 23,000 bone and muscle samples, including all orthopaedic malignancies as well as other benign and non-tumour tissue types. All samples are held within our secure and fully licenced facility at -80ﹾC with continual temperature monitoring.
    The ROH Research Tissue Banks’ ethical approval and HTA Licence permits the release of anonymised materials and corresponding clinical data for approved research programmes. Prospectively collected blood and tissue samples, which are collected and processed to meet specific study requirements, can also be released by the Research tissue Bank with appropriate patient consent.

    How to access material from the Research Tissue Bank

    We recommend an early discussion with our research tissue bank Manager to discuss the requirements of your study and its eligibility to access RTB tissues under the tissue banks current ethical approvals and HTA licence. Once eligibility is confirmed our Tissue Bank Manager will support you in providing an indicative costing and in applying for permission to access the required material via our Independent Scientific Advisory Panel who will undertake the Tissue Access Review in accordance with our ethical approvals and licence.
    For more information on how to access materials from the Research Tissue Bank, please contact This email address is being protected from spambots. You need JavaScript enabled to view it..